False-Positive Quantiferon Results at a Large Healthcare Institution

False-positive quantiferon results at a large healthcare institution.

TO THE EDITOR—Eighteen million US healthcare workers (HCWs) undergo mandatory annual screening for latent tuberculosis [1]. Screening is also performed in tuberculosis contacts, immunocompromised patients, and other individuals employed in the public sector. Many institutions have switched from the tuberculin skin test to the Quantiferon (QFT) assay for latent tuberculosis screening. In recent ...

Defective antigen tubes generate false-positive QuantiFERON tuberculosis test results.

TO THE EDITOR—In recent years a significant shift in testing has occurred for diagnosing latent tuberculosis (LTB). The adoption of interferon gamma release assays (IGRA) has largely supplanted tuberculin skin test (TST) for both patient testing and employee screening. IGRA have advantages over TST in that they are unaffected by prior vaccination with bacillus Calmette–Guérin (BCG) vaccine and ...

1294Skin Microbiota Contamination Causes False Positive QuantiFERON-TB Results

HIV false positive results and Flu vaccination

Abstract False positive results are the major problem influencing interpretation of Clinical Laboratory test. They are originated mostly in the other diseases, technical errors and the recent vaccination. The problem has been presented since 1991 is positive HIV test after influenza Vaccination (1). The False positive has been reported in Cases using Eliza, one of The most common test to screen...

Investigation of false-positive results given by the QuantiFERON-TB Gold In-Tube assay.

We investigated a sudden increase in the rate of positive QuantiFERON-TB Gold In-Tube results from 10% to 31% at a U.S. academic institution. Direct comparison of the TB antigen tubes with tubes from a different lot number identified that a potential problem with the TB antigen vials in a certain tube lot was the likely cause of the elevated positive rate. The underlying defect remains unknown....